Apilimod mesylate for cell activation

Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases through the prevention of nuclear translocation of c-Rel. It suppresses the Th1, but not the Th2, response, resulting in reduced inflammation in a mouse model of inflammatory bowel disease. Apilimod inhibits the production of IL-23p19 and IL-12/IL-23p40 subunits while decreasing skin inflammation in a clinical study of patients with psoriasis. Apilimod inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC₅₀ = 14 nM), which is necessary and sufficient for suppression of IL-12/IL-23p40 expression.

N/A

870087-36-8 

610.7

Biochemicals

(E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

C₂₅H₃₄N₆O₈S₂

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

gel pack

36 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.