Rat Renin Inhibitor Screening Kit (Fluorometric)

Catalog number
Rat Renin Inhibitor Screening Kit (Fluorometric)
100 assays
732.00 EUR


Kit's description
Renin (EC, also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Rat Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Rat Renin inhibitor, the rate of hydrolysis of the substrate is decreased or inhibited. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of rat renin inhibitors. It is also adaptable to a 384-well format.
• Detection Method – Fluorescence (Ex/Em = 328/552 nm) • Application: : Screening potential inhibitors of rat renin : Characterize/study rat renin inhibitors
Kit's benefits
• Rapid & HTS • Reliable test for screening/studying/characterizing potential inhibitors of rat renin • Includes Inhibitor Control
Rat Renin
Kit's other name
• Renin Assay Buffer • Rat Renin Substrate • Rat Renin Enzyme (lyophilized) • Rat Renin Inhibitor (lyophilized)
Storage condition
Shipping condition
gel pack
Maximum time can be stored
12 months
Species reactivity
see datasheet
• Screening/Characterizing/studying potential inhibitors of rat renin
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name
Rattus norvegicus