anti-Bad monoclonal Antibody
anti-Bad monoclonal Antibody
Bad monoclonal Antibody
Target of this antibody:
Alternative names of antibody target:
BAD antibody,BAD human antibody,BBC 2 antibody,BBC2 antibody,BBC6 antibody,Bcl 2 Antagonist of Cell Death antibody,Bcl 2 Binding Component 6 antibody,BCL X / BCL 2 Binding Protein antibody,BCL X Binding Protein antibody,Bcl XL/Bcl 2 Associated Death Promoter antibody,Bcl-2-binding component 6 antibody,Bcl-2-like protein 8 antibody,Bcl-XL/Bcl-2-associated death promoter antibody,Bcl2 antagonist of cell death antibody,BCL2 antagonist of cell death protein antibody,BCL2 associated agonist of cell death antibody,Bcl2 Associated Death Promoter antibody,BCL2 binding component 6 antibody,BCL2 binding protein antibody,Bcl2 Like 8 Protein antibody,Bcl2-L-8 antibody,BCL2L8 antibody,BclXL antibody,Proapoptotic BH3 Only Protein antibody.
Bad is a member of the Bcl-2 family proteins. Within the Bcl-2 homology domains 1 and 2 (BH1 and BH2), Bad shows significant homology to Bcl-2 and Bcl-x. Bcl-2 is known to block several apoptosis signals and is considered to be a central downstream cell death repressor. Bcl-XL represses apoptosis, but its short form, Bcl-XS, promotes cell death. Bax is known to homodimerize as well as heterodimerize with Bcl-2. An excess concentration of Bax opposes the ability of Bcl-2 to repress cell death. Bad can selectively dimerize with Bcl-xL and Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1, or itself. In mammalian cells, Bad binds more strongly to Bcl-xL than Bcl-2, which may explain why Bad reverse the death repressor activity of Bcl-xL, but not that of Bcl-2. The formation of the Bad-Bcl-xL heterodimer displaces Bax and restores favorable conditions for apoptosis.
Clonality of antibody:
This antibody reacts with:
Human, Mouse, Rat
Full length human Bad
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
100 µg (200 µg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol.
Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods:
Western blot: 1-4 µg
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.