Jumonji HDM Inhibitor, PBIT for cell activation

Catalog number
2475-25
Name
Jumonji HDM Inhibitor, PBIT for cell activation
Size
25 mg
Price
632.00 EUR
Supplier

Details

Description
PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.
Peptide sequence
N/A
CAS number
2514-30-9
Molecular weight
241.31
Category
Biochemicals
Other name
2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
Molecular formula
C₁₄H₁₁NOS
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.