Dofetilide for cell activation

Catalog number
B1189-5
Name
Dofetilide for cell activation
Size
5 mg
Price
142.00 EUR
Supplier

Details

Description
Dofetilide is a class III antiarrhythmic agent and inhibits the rapid delayed rectifier K⁺current (IKr) with IC₅₀values of 31.5 nM in guinea pig cardiomyocytes. At higher doses it demonstrates pro-arrhythmic activity in cell models. Therefore, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm and in the maintenance of sinus rhythm after conversion.
Peptide sequence
N/A
CAS number
115256-11-6
Molecular weight
441.56
Category
Biochemicals
Other name
1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Molecular formula
C₁₉H₂₇N₃O₅S₂
Physical appearance
White Solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.