Target of this antibody:
Alternative names of antibody target:
ALK tyrosine kinase receptor (EC 22.214.171.124) (Anaplastic lymphoma kinase) (CD antigen CD246)
ALK (anaplastic lymphoma kinase) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The NPM-ALK is a constitutively active oncogenic tyrosine kinase associated with anaplastic lymphoma. Activation of PLCgamma by NPM-ALK has been sμggested as a crucial step for this lymphoma-associated oncogenic tyrosine kinase.
Clonality of antibody:
This antibody reacts with:
Synthetic peptide corresponding to C-terminus of human ALK
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
100 µg (0.5 mg/ml) rabbit anti-ALK polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
This antibody has been succesfully tested for use in following methods:
Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.