anti-COCO/DAND5 Antibody

Catalog number
anti-COCO/DAND5 Antibody
COCO/DAND5 Antibody
338.00 EUR


Target of this antibody:
Alternative names of antibody target:
DANTE, CKTSF1B3, DAN domain family member 5, Cerberus-like 2 protein
Background information:
COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and Cerberus (DAND4). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF­β superfamily ligands such as BMPs that play important roles in tissue morphogenesis and developmental processes. COCO has eight Cys residues in the cysteine knot which places it in the CAN (or eight­membered ring) subfamily of BMP antagonists along with the other DAN family proteins. In Xenopus embryos, COCO is expressed by pluripotent ectodermal cells. Expression is abruptly downregulated prior to gastrulation, and the loss of ectodermal cell pluripotency is coincident with COCO downregulation. COCO is required for Xenopus left­right axis formation. It functions predominantly on the right side of the embryo, although it is equally expressed on both left and right sides. COCO binds and inhibits activin, BMP­4, GDF3/derrière, Wnt8, and Xnr1. In mouse, COCO expression is elevated on the right side of Henson’s node at the early somite stage, in contrast to the left side expression of Nodal.
Antibody host:
Clonality of antibody:
Rabbit IgG
This antibody reacts with:
Human, mouse, rat
Immunogene sequence:
Synthetic peptide at C-terminal (BV-MM26)
Concentration of antibody:
0.5 mg/ml
Form of antibody:
Formulation of this antibody:
100 µg (0.5 mg/ml) of antibody in PBS containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2.
Purification method:
Affinity purified
This antibody has been succesfully tested for use in following methods:
Western blot
Recommended usage:
Western blot: 1:200
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation