anti-FOXO3a Antibody

Catalog number
3673-100
Name
anti-FOXO3a Antibody
Size
FOXO3a Antibody
Price
316.00 EUR
Supplier

Details

Target of this antibody:
FOXO3a
Alternative names of antibody target:
FOXO3A , 602681 , O43524 , AF6q21 , DKFZp781A0677 ,FKHRL1 , FKHRL1P2 , MGC12739 , MGC31925
Background information:
Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes, including the cell cycle, apoptosis, DNA repair, stress resistance, and metabolism. FOXO proteins are negatively regulated by the phosphatidylinositol 3-kinase-Akt signaling pathway, which is activated by growth factors and cytokines. Recent studies indicate that the activities of FOXO proteins are also regulated by oxidative stress, which induces their phosphorylation, translocation to the nucleus, and acetylation-deacetylation. Similar to the tumor suppressor p53, FOXO is activated by stress and induces the expression of genes that contribute to cell-cycle arrest, sμggesting that it also functions as a tumor suppressor.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
This antibody reacts with:
Human, mouse
Immunogene sequence:
Synthetic peptide corresponding to residues on the C-terminus of human FOXO3a
Concentration of antibody:
0.2 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 µg (0.2mg/ml) affinity purified rabbit anti-FOXO3a polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.
Purification method:
Affinity purified
This antibody has been succesfully tested for use in following methods:
Western blot, Immunoprecipitation
Recommended usage:
Western blotting (0.5-4 µg/ml). Jurkat cell lysate (Cat.# 2401-100) and rat liver or rat kidney tissue lysate can be used as a positive control. A ~75 kDa band should be detected.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps