anti-LAMP-2 Antibody (CT)

Catalog number
5078-100
Name
anti-LAMP-2 Antibody (CT)
Size
LAMP-2 Antibody (CT)
Price
403.00 EUR
Supplier

Details

Target of this antibody:
LAMP-2
Alternative names of antibody target:
LAMP-2, Lysosome associated membrane protein 2
Background information:
Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG1
This antibody reacts with:
Human, mouse
Immunogene sequence:
LAMP-2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LAMP-2.
Concentration of antibody:
1 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Purification method:
Affinity chromatography purified via peptide column.
This antibody has been succesfully tested for use in following methods:
Western blot, Immunocytochemistry, ELISA
Recommended usage:
Western Blot: 1 - 2 μg/ml, Immunocytochemistry: 10 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps