anti-SHANK3 Antibody (Center)

Catalog number
anti-SHANK3 Antibody (Center)
SHANK3 Antibody (Center)
458.00 EUR


Target of this antibody:
Alternative names of antibody target:
SH3 and multiple ankyrin repeat domains 3, ProSAP2, PSAP2, SPANK-2, Proline-rich synapse-associated protein 2
Background information:
SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
Antibody host:
Clonality of antibody:
Rabbit IgG1
This antibody reacts with:
Human, Mouse
Immunogene sequence:
SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.
Concentration of antibody:
1 mg/ml
Form of antibody:
Formulation of this antibody:
100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Purification method:
Affinity chromatography purified via peptide column
This antibody has been succesfully tested for use in following methods:
Western blot, IHC, ELISA
Recommended usage:
Western Blot: 1 μg/ml, IHC: 2.5 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation