anti-TIP60 Antibody

TIP60

Lysine Acetyltransferase 5; KAT5

TIP60, originally isolated as an HIV-1 TAT-interactive protein, is known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyltransferases (HATs). TIP60 is a catalytic subunit of the NuA4 HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thoμght to play an important role in signal transduction.

Rabbit

Polyclonal

Rabbit IgG

Human, chimpanzee, orangutan, equine, canine, mouse, bovine, rat, opossum, zebrafish, xenopus

Synthetic peptide within the region of human TIP60 amino acids 480-530.

N/A

Liquid

50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.

Protein A purified

Western blot, Immunohistochemistry

Western blot: 0.25-1.0 µg/ml, IHC (paraffin embedded sections): 5 µg/ml. However, the optimal conditions should be determined individually.

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps