Target of this antibody:
Alternative names of antibody target:
Serine/threonine-protein kinase GSK3A, GSK-3alpha, Glycogen synthase kinase-3, GSK-3 alpha
Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase. GSK-3 phosphorylates and inactivates glycogen synthase. It has also been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate Cyclin D1 proteolysis and subcellular localization. GSK-3alpha (GSK-3α) regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer's disease, by phosphorylating Tau proteins. This presents the possibility that defects in GSK-3 signaling can contribute to the onset of Alzheimer’s disease. GSK-3α can be phosphorylated by Akt at Ser21. This phosphorylation of GSK-3α negatively regulates its kinase activity.
Clonality of antibody:
This antibody reacts with:
Human recombinant GSK-3α (Cat # 7003)
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
30 µg (0.5 mg/ml) of GSK-3α antibody in PBS pH 7.2, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Affinity Purified Antibody
This antibody has been succesfully tested for use in following methods:
Western blot: 1-4 µg
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.