IGF-I, rat recombinant

Catalog number
4121-20
Name
IGF-I, rat recombinant
Size
20 μg
Price
345.00 EUR
Supplier

Details

Synonyms
Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.
Alternates names
Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.
Taglines
An endocrine hormone binding to IGF1R
Biomolecule/Target
IGF-I
NCBI Gene ID #.
24482
NCBI Gene Symbol
Igf1
Gene Source
Rat
Accession #
P08025
Recombinant
Yes
Source
E. coli
Purity
≥95%
Activity (Specifications/test method)
N/A
Biological activity
The ED₅₀ was determined by two methods: 1) By stimulation of protein synthesis in rat L6 myoblasts, the ED₅₀ was found to be
Results
<10 ng/ml.
Molecular Weight
7.69 kDa
Storage Temp.
-20°C
Shipping
Blue ice
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized protein
Physical form description
Sterile filtered and lyophilized with no additives
Reconstitution Instructions
Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name
Rattus norvegicus
Additional source
Recombinants or rec. proteins
Group
recombinants