anti-BMPR2 Antibody (NT)

Catalog number
anti-BMPR2 Antibody (NT)
BMPR2 Antibody (NT)
338.00 EUR


Target of this antibody:
Alternative names of antibody target:
BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II
Background information:
BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.
Antibody host:
Clonality of antibody:
Rabbit IgG
This antibody reacts with:
Human, Mouse.
Immunogene sequence:
This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
In PBS with 0.09% (W/V) sodium azide.
Purification method:
Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
This antibody has been succesfully tested for use in following methods:
Western blot, IHC, FACS.
Recommended usage:
WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation