R³ IGF-1, human recombinant

Catalog number
4216-50MG
Name
R³ IGF-1, human recombinant
Size
50 mg
Price
3145.00 EUR
Supplier

Details

Synonyms
insln-like Growth Factor-I, Somatamedin C, IGF-IA
Alternates names
insln-like Growth Factor-I, Somatamedin C, IGF-IA, Mechano growth factor
Taglines
Highly potent form of endocrine hormone IGF-1
Biomolecule/Target
R3 IGF-1
NCBI Gene ID #.
3479
NCBI Gene Symbol
IGF1
Gene Source
Human
Accession #
P01343
Recombinant
Yes
Source
E. coli
Purity
≥97%
Activity (Specifications/test method)
N/A
Biological activity
The ED₅₀ as determined by a cell proliferation assay using NIH3T3 cells is typically 1-6 ng/ml.
Results
1-6 ng/ml.
Molecular Weight
9.11 kDa
Storage Temp.
-20°C
Shipping
Gel pack
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized protein
Physical form description
Lyophilized with no additives
Reconstitution Instructions
Reconstitute in dH₂O or 10 mM AcOH to 1.0 mg/ml. This solution can then be diluted into other buffered solutions or stored at 4°C for 1 week or –20°C for future use.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Additional source
Recombinants or rec. proteins
Group
recombinants