Target of this antibody:
Alternative names of antibody target:
Sterol regulatory element-binding protein 2, SREBF2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2
SREBP2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.2 SREBP2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
Clonality of antibody:
This antibody reacts with:
This SREBF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the Central region of human SREBP2.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
In PBS with 0.09% (W/V) sodium azide.
This antibody is purified through a protein A column, followed by peptide affinity purification
This antibody has been succesfully tested for use in following methods:
WB: ~1:1000, IF: 1:10-50, IHC-P: 1:10-50.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.