Target of this antibody:
Alternative names of antibody target:
Erythropoietin-Alpha, EPO-a, EPO-alpha, Epoetin, EP, MGC138142
Human erythropoietin (EPO) is an acidic glycoprotein. It is mainly produced by the kidney. As the primary regulator of the production of red cells, its major functions are to promote erythroid progenitor cells differentiation and to start the synthesis of hemoglobin. EPO acts by binding to a specific erythropoietin receptor (EPOR) on target cells; the red cell precursors in the bone marrow, and induces their transformation into mature erythrocytes. The EPO sensitivity increases with differentiation of immature progenitor cells. EPO may act as a neuron protector against glutamate toxicity. Its neuroprotective activity comes into effect by neutralizing the toxicity of free radicals. EPO is produced in brain after oxidative stress. EPO is upregulated by hypoxia and prevents apoptosis of erythroid progenitors in bone.
Clonality of antibody:
This antibody reacts with:
Human CellExp™ EPO, Human Recombinant (Cat # 6447)
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
1 mg/ml in PBS with 0.007% (W/V) sodium azide
This antibody is purified through a protein A affinity chromatography.
This antibody has been succesfully tested for use in following methods:
WB - 1:10,000-20,000
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.