Target of this antibody:
Alternative names of antibody target:
P-gp, Multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B (MDR/TAP) member 1, ABCB1
P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.
Clonality of antibody:
This antibody reacts with:
Human, Mouse, Rat
Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3
Immunogen affinity purified antibody
This antibody has been succesfully tested for use in following methods:
IHC: 1:500-1:1000 of 0.5 mg/ml stock
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The vial should be centrifuged to collect the lyophilized solid before reconstituting
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.