Target of this antibody:
Alternative names of antibody target:
Myocyte-specific enhancer factor 2C, MEF2C
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Clonality of antibody:
This antibody reacts with:
synthetic human MEF2C peptide (Gln 365 – Asp 400)
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.
Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods:
Western Blot, Immunofluorescent staining, Immunohistochemistry
Western Blot 1:1000; Immunofluorescent staining 1:10~50; Immunohistochemistry 1:10~50
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.