anti-Phospho-FoxO1 (Ser319) antibody

Catalog number
A1018-100
Name
anti-Phospho-FoxO1 (Ser319) antibody
Size
Phospho-FoxO1 (Ser319) antibody
Price
360.00 EUR
Supplier

Details

Target of this antibody:
FoxO1 (Ser319)
Alternative names of antibody target:
FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma
Background information:
Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and survival. Within the family, three members (FoxO1, FoxO4, and FoxO3a) have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt. The FoxO signaling is regulated by their interactions with other intracellular proteins as well as their post-translational modifications such as phosphorylation. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
Rabbit IgG
Clone:
N/A
This antibody reacts with:
Human, Mouse, Rat
Immunogene sequence:
Synthesized peptide derived from human FoxO1 around the phosphorylation site of S319
Concentration of antibody:
1mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification method:
Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods:
WB, IHC, ELISA
Recommended usage:
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps