anti-Anti-TNF-α (Adalimumab), humanized Antibody

Catalog number
A1048-100
Name
anti-Anti-TNF-α (Adalimumab), humanized Antibody
Size
Anti-TNF-α (Adalimumab), humanized Antibody
Price
371.00 EUR
Supplier

Details

Target of this antibody:
TNF-α
Alternative names of antibody target:
Humira
Background information:
Adalimumab (Humira), a human monoclonal antibody that specifically binds to tumor necrosis factor-alpha (TNF-a). Possessing a high specificity and affinity for TNFα adalimumab exerts its therapeutic effects by blocking the interaction of TNFα with the p55 and p75 receptors as well as inducing apoptosis of TNF-expressing mononuclear cells. Adalimumab can be used for the treatment of Rhcumatoid arthritis, Juvenilc Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease and Plaque Psoriasis.
Antibody host:
Human
Clonality of antibody:
Monoclonal
Isotype:
Human IgG1
This antibody reacts with:
Human
Immunogene sequence:
Recombinant human TNF a
Concentration of antibody:
2 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 ug (2mg/ml) of antibody in Phosphate buffered saline, pH 7.4.
Purification method:
human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.
This antibody has been succesfully tested for use in following methods:
Neutralization, ELISA
Recommended usage:
Neutralization : 0.01-1 μg/ml; ELISA: 1μg/ml
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
French translation
anticorps