anti-Anti-EGFR (Panitumumab), humanized antibody

EGFR

Vectibix

Panitumumab is the human monoclonal antibody against epidermal growth factor receptor (EGFR). The EGFR is a member of a subfamily of type I receptor tyrosine kinases, including EGFR (HERl, c-ErbB-l), HER2/neu, HER3, and HER4. EGFR is a transmembrane glycoprotein that is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Overexpression of EGFR is also detected in many human cancers, including those of the colon and rectum. Panitumumab binds specifically and selectively to the EGFR, preventing binding of activating ligands, such as the EGF and transforming growth factor-α. This binding results in blockade of the essential downstream signaling pathways that are known to govern apoptosis, proliferation and differentiation of both normal and neoplastic cell types in a wide array of tissues.

Human

Monoclonal

Human IgG1

Human

EGFR

2 mg/ml

Liquid

100 ug (2mg/ml) of antibody in Phosphate buffered saline, pH 7.4.

human IgG2k was expressed in a mouse cell line. IgG was purified from mouse cell culture supernatant by protein A chromatography.

Neutralization, ELISA

Neutralization : 1-20μg/ml; ELISA: 1μg/ml

Shelf time: 12 months in temp.: -20 deg.C

gel pack

The antibody solution should be gently mixed before use

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

anticorps