CXCL16, mouse recombinant

Catalog number
4353-1000
Name
CXCL16, mouse recombinant
Size
1 mg
Price
4618.00 EUR
Supplier

Details

Target
CXCL16
Background
Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membrane bound and soluble forms. CXCL16 is expressed in the spleen, lymph nodes, Peyer patches non-lymphoid tissues (e.g. lung, kidney, small intestine, thymus). It is weakly expressed in heart and liver and not expressed in brain and purified B- and T-cells. CXCL16 deficiency is linked to breast cancer progression and is involved in immunological liver injury (by regulating T lymphocyte infiltration). CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells, and in the production of IFN-gamma by NKT cells and promotion of Th1-inclined immune responses mediated by NKT cells. CXCL16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 9.9kDa. The CXCL16 is purified by proprietary chromatographic techniques.
Concentration
N/A
Molecular weight
9.9 kDa
Synonym
C-X-C motif chemokine 16, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX, Cxcl16, Srpsox, Zmynd15, AV290116, BB024863, 0910001K24Rik.
Other name
C-X-C motif chemokine 16, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX, Cxcl16, Srpsox, Zmynd15, AV290116, BB024863, 0910001K24Rik.
NCBI gene number
66102
NCBI gene
CXL16
Gene source
Mouse
NCBI number
Q8BSU2
Recombinant
Yes
Source
E. coli
Purification
≥97%
Tested applications
SDS-PAGE, HPLC
Level of endotoxin
N/A
Tested activity
N/A
Biological activity
N/A
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized protein
Physical properties
Lyophilized from a filtered solution containing 20 mM sodium phosphate buffer, pH 7.4 and 50 mM NaCl.
How to reconstitute
Reconstitute in sterile ddH₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Aa sequence
NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name
Mus musculus
Additional source
Recombinants or rec. proteins
Group
recombinants