anti-Anti-EGFR (Matuzumab), Human IgG1 Antibody

Catalog number
A1090-200
Name
anti-Anti-EGFR (Matuzumab), Human IgG1 Antibody
Size
Anti-EGFR (Matuzumab), Human IgG1 Antibody
Price
697.00 EUR
Supplier

Details

Target of this antibody:
EGFR
Alternative names of antibody target:
Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Background information:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
Antibody host:
Recombinant
Clonality of antibody:
Monoclonal
Isotype:
Human IgG1, kappa
This antibody reacts with:
Human
Immunogene sequence:
Domain III of the extracellular domain of human EGRF.
Form of antibody:
Liquid
Formulation of this antibody:
200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification method:
Affinity purified using protein A
This antibody has been succesfully tested for use in following methods:
Block; FC; WB
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
French translation
anticorps