anti-Anti-CD4 (Clenoliximab), Human IgG4 Antibody

Catalog number
A1091-200
Name
anti-Anti-CD4 (Clenoliximab), Human IgG4 Antibody
Size
Anti-CD4 (Clenoliximab), Human IgG4 Antibody
Price
697.00 EUR
Supplier

Details

Target of this antibody:
CD4
Alternative names of antibody target:
p55; T cell surface antign T4/Leu-3.
Background information:
The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.
Antibody host:
Recombinant
Clonality of antibody:
Monoclonal
Isotype:
Human IgG4, lambda
Clone:
CE9.1
This antibody reacts with:
Human, Chimpanzee
Immunogene sequence:
Domain 1 of human CD4.
Form of antibody:
Liquid
Formulation of this antibody:
200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification method:
Affinity purified using protein A
This antibody has been succesfully tested for use in following methods:
ELISA; FC; Block; SPR; IHC
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.CD4+ T helper cell marker or cluster differentiator of white blood cells in FACS or flow cytometry. Used offer coupled to magnetic beads. GENTAUR makes custom magnetic bead couplings on 50 and 250 nm beads for certain clones.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
French translation
anticorps