anti-Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

Catalog number
A1092-200
Name
anti-Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody
Size
Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody
Price
697.00 EUR
Supplier

Details

Target of this antibody:
ITGA5
Alternative names of antibody target:
Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e
Background information:
The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
Antibody host:
Recombinant
Clonality of antibody:
Monoclonal
Isotype:
Human IgG4, kappa
Clone:
M200
This antibody reacts with:
Human
Immunogene sequence:
Heterodimeric α5β1Fc fusion protein
Form of antibody:
Liquid
Formulation of this antibody:
200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification method:
Affinity purified using protein A
This antibody has been succesfully tested for use in following methods:
ELISA; FC; IF; Block; IHC
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use
Description
The anti-Anti-alpha 5 beta 1 Integrin (Volociximab) IgG4 Antibody is a α- or alpha protein sometimes glycoprotein present in blood.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
French translation
anticorps