Follistatin, human recombinant

Catalog number

4708-20

Size

20 μg

Price

246.00 EUR

Supplier

Biovision

Order

Details

Background

Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF-β ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring antagonist binds to Activin, BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids including 36 cysteine residues.

Concentration

N/A

Molecular weight

31.5 kDa

Synonym

FST, FS, Activin-binding protein

Other name

FST, FS, Activin-binding protein

NCBI gene number

10468

NCBI gene

FST

Gene source

Human

NCBI number

P19883

Recombinant

Yes

Source

E. coli

Purification

≥95%

Tested applications

SDS-PAGE, HPLC

Tested activity

N/A

Biological activity

Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED₅₀ is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.

Reesults

0.1-0.4 µg/ml

Binding ability

N/A

Unit

N/A

Storage condition

-20°C

Shipping under

Gel pack

Physical appearance

Lyophilized protein

Physical properties

Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl

How to reconstitute

Reconstitute in H₂O to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Aa sequence

N/A

Before use

Centrifuge the vial prior to opening.

Notes

For Research Use Only! Not to be used in humans

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Additional source

Recombinants or rec. proteins

Group

recombinants