Human CellExp™ Progranulin, Human Recombinant

Catalog number
4738-10
Name
Human CellExp™ Progranulin, Human Recombinant
Size
10 µg
Price
306.00 EUR
Supplier

Details

Background
Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.
Concentration
0.5 mg/ml
Molecular weight
88.0 kDa
Synonym
Acrogranin, Paragranulin, Granulin-1
Other name
Acrogranin, Paragranulin, Granulin-1
NCBI gene number
2896
NCBI gene
GRN
Gene source
Human
NCBI number
P28799
Recombinant
Yes
Source
HEK 293 cells
Purification
≥90%
Tested applications
SDS-PAGE, HPLC
Level of endotoxin
N/A
Tested activity
N/A
Biological activity
Measured by chemotaxis using THP-1 cells.
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Liquid
Physical properties
Sterile filtered clear solution in PBS
How to reconstitute
N/A
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants