Caspase-12 Inhibitor Z-ATAD-FMK for cell activation

Catalog number
1079-20C
Name
Caspase-12 Inhibitor Z-ATAD-FMK for cell activation
Size
20 µl (10 mM)
Price
208.00 EUR
Supplier

Details

Description
A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Peptide sequence
Z-Ala-Thr-Ala-Asp(OMe)-FMK
CAS number
N/A
Molecular weight
540.54
Category
Caspase Inhibitor
Other name
Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
Molecular formula
C₂₄H₃₃N₄O₉F
Physical appearance
Liquid
Supplied with
DMSO ( 10 mM)
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>95% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.