Caspase Inhibitor Boc-D-FMK for cell activation

Catalog number
1120-20C
Name
Caspase Inhibitor Boc-D-FMK for cell activation
Size
20 µl (10 mM)
Price
186.00 EUR
Supplier

Details

Description
A synthetic peptide that irreversibly inhibits ICE-family protease/caspase activity and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Peptide sequence
Boc-Asp(OMe)-FMK
CAS number
N/A
Molecular weight
263.26
Category
Caspase Inhibitor
Other name
Boc-D-FMK, Caspase Inhibitor (fluoromethylketone)
Molecular formula
C₁₁H₁₈FNO₅
Physical appearance
Liquid
Supplied with
DMSO (10 mM)
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>99% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.