FAS Inhibitor, C75 for cell activation

Catalog number
1547-1
Name
FAS Inhibitor, C75 for cell activation
Size
1 mg
Price
170.00 EUR
Supplier

Details

Description
Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
Peptide sequence
N/A
CAS number
191282-48-1
Molecular weight
254.3
Category
Biochemicals
Other name
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
Molecular formula
C₁₄H₂₂O₄
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (18 mg/ml)
Storage condition
-20°C
Shipping condition
RT
Maximum time for storage
24months
Storage instructions
Protect from light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.