Human Recombinant TNF-beta/LTA

Catalog number
6376-50
Name
Human Recombinant TNF-beta/LTA
Size
50 μg
Price
475.00 EUR
Supplier

Details

Synonyms
Human Recombinant TNF-beta/LTA
Alternates names
Lymphotoxin alpha, LT, TNFB, TNFSF1.
Taglines
Mediates a large variety of inflammatory, immunostimulatory, and antiviral responses
Biomolecule/Target
NA
NCBI Gene ID #.
4049
NCBI Gene Symbol
LTA
Gene Source
Human
Accession #
P01374
Recombinant
Yes
Source
E. Coli
Purity
N/A
Endotoxin Level
N/A
Activity (Specifications/test method)
N/A
Biological activity
Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is
Molecular Weight
20.9 kDa (192 aa, 35-205 aa + His-Tag)
Storage Temp.
-20°C
Shipping
gel pack
Shelf Life
1 year
Concentration
0.5 mg/ml
Appearance
Liquid
Physical form description
0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol.
Reconstitution Instructions
N/A
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants
Gene
Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.