Cyclopamine for cell activation

Catalog number
1578-5
Name
Cyclopamine for cell activation
Size
5 mg
Price
273.00 EUR
Supplier

Details

Description
Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle
Peptide sequence
N/A
CAS number
4449-51-8
Molecular weight
411.62
Category
Biochemicals
Other name
11-deoxojervine
Molecular formula
C₂₇H₄₁NO₂
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99%
Reconstitute instructions
DMSO (4 mg/ml) and EtOH (5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24months
Storage instructions
Teratogen!
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.