Canertinib (CI-1033, PD-183805) for cell activation

Catalog number
1617-50
Name
Canertinib (CI-1033, PD-183805) for cell activation
Size
50 mg
Price
387.00 EUR
Supplier

Details

Description
Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
Peptide sequence
N/A
CAS number
289499-45-2
Molecular weight
558.86
Category
Biochemicals
Other name
CI-1033, PD-183805, PD 183806
Molecular formula
C₂₄H₂₅ClFN₅O₃ . 2HCl
Physical appearance
Off-white to pale green solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99%
Reconstitute instructions
DMSO (100 mg/ml)
Storage condition
-20°C
Shipping condition
RT
Maximum time for storage
24months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.