Human CellExp™ FLT-3 Ligand, Human Recombinant

Catalog number
6452-50
Name
Human CellExp™ FLT-3 Ligand, Human Recombinant
Size
50 μg
Price
1154.00 EUR
Supplier

Details

Background
FLT3 ligand is a receptor for the Flt3 cytokine and has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation. Human flt3-Ligand (flk2-ligand) stimulates the proliferation and colony formation of certain bone marrow precursor cells including CD34+ cells.
Concentration
N/A
Molecular weight
24 to 30 kDa, monomer, glycosylated
Synonym
Human Cellexp Human Recombinant FLT-3 Ligand
Other name
Fms-related tyrosine kinase 3 ligand, FLK2, STK1, CD135, Stem Cell Tyrosine Kinase 1, FLT3LG, Flt3.
NCBI gene number
2322
NCBI gene
FLT3
Gene source
Human
NCBI number
P36888
Recombinant
Yes
Source
Human 293 cell expressed
Purification
≥95%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
<1.0 EU per 1 μg of protein
Tested activity
N/A
Biological activity
ED₅₀ is typically 0.2 to 0.8 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of the human acute myeloid leukemia cell line OCI-AML5.
Reesults
0.2 to 0.8 ng/ml
Binding ability
N/A
Unit
N/A
Storage condition
-80°C
Shipping under
gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from a PBS solution.
How to reconstitute
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Additional source
Recombinants or rec. proteins
Group
recombinants