SIRT2 Inhibitor, AGK2 for cell activation

Catalog number
1651-10
Name
SIRT2 Inhibitor, AGK2 for cell activation
Size
10 mg
Price
229.00 EUR
Supplier

Details

Description
A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is>15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.
Peptide sequence
N/A
CAS number
304896-28-4
Molecular weight
434.27
Category
Biochemicals
Other name
AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Molecular formula
C₂₃H₁₃Cl₂N₃O₂
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO
Storage condition
+4°C
Shipping condition
RT
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.