SIRT1 Inhibitor, EX-527 for cell activation

Catalog number
1652-10
Name
SIRT1 Inhibitor, EX-527 for cell activation
Size
10 mg
Price
229.00 EUR
Supplier

Details

Description
A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
Peptide sequence
N/A
CAS number
49843-98-3
Molecular weight
248.71
Category
Biochemicals
Other name
EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Molecular formula
C₁₃H₁₃ClN₂O
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (20 mg/ml)
Storage condition
+4°C
Shipping condition
RT
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.