L-685, 458 for cell activation

Catalog number
1713-250
Name
L-685, 458 for cell activation
Size
250 µg
Price
273.00 EUR
Supplier

Details

Description
Cell-permeable. A potent and selective γ-secretase inhibitor (IC₅₀ = 17 nM) .Displays> 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC₅₀ values are 48 and 67 nM respectively in human neuroblastoma cells).
Peptide sequence
N/A
CAS number
292632-98-5
Molecular weight
672.85
Category
Biochemicals
Other name
5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Molecular formula
C₃₉H₅₂N₄O₆
Physical appearance
Liquid
Supplied with
1 mM solution in DMSO (250 µg in 372 µl)
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.