TGR5 Receptor Agonist for cell activation

Catalog number
1722-5
Name
TGR5 Receptor Agonist for cell activation
Size
5 mg
Price
327.00 EUR
Supplier

Details

Description
Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells.
Peptide sequence
N/A
CAS number
N/A
Molecular weight
361.22
Category
Biochemicals
Other name
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide
Molecular formula
C₁₈H₁₄Cl₂N₂O₂
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.