Stat3 Peptide Inhibitor, Cell-Permeable for cell activation

Catalog number
1778-1
Name
Stat3 Peptide Inhibitor, Cell-Permeable for cell activation
Size
1 mg
Price
229.00 EUR
Supplier

Details

Description
Cell-permeable. A peptide-based inhibitor, PY*LKTK-mts (mts = membrane translocating sequence) that selectively inhibits constitutive and ligand-induced activation of Stat3 in vivo. Also suppresses transformation by Src oncoprotein that requires constitutive Stat3 activation.
Peptide sequence
H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH. CF3CO2H
CAS number
N/A
Molecular weight
1958.32 . 114.02
Category
Biochemicals
Other name
PY*LKTK-mts (where Y* = phosphotyrosine)
Molecular formula
C₉₂H₁₅₇N₂₀O₂₄P .C₂HF₃O₂
Physical appearance
White lyophilized solid
Supplied with
N/A
Is this a salt?
Yes
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
H₂O
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.