IKK-ε Kinase Inhibitor II for cell activation

Catalog number
1811-1
Name
IKK-ε Kinase Inhibitor II for cell activation
Size
1 mg
Price
159.00 EUR
Supplier

Details

Description
A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC₅₀ = 40 nM); displays>125-fold selectivity over IKK-α and IKK-β.
Peptide sequence
N/A
CAS number
862812-98-4
Molecular weight
469.53
Category
Biochemicals
Other name
5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile
Molecular formula
C₂₂H₁₉N₃O₅S₂
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.