Stat3 Activation Inhibitor, SPI for cell activation

Catalog number
1813-2
Name
Stat3 Activation Inhibitor, SPI for cell activation
Size
2 mg
Price
229.00 EUR
Supplier

Details

Description
Cell-permeable. A potent and selective inhibitor of Stat3 SH2 domain:pTyr interactions; also disrupts the binding of Stat3 to the IL-6R/gp130 peptide, GpYLPQTVNH₂ and induces antitumor effects in vitro.
Peptide sequence
H-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Thr-Lys-Pro-Pro-Gly-Thr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
CAS number
N/A
Molecular weight
3225.74. 114.02
Category
Biochemicals
Other name
FISKERERAILSTKPPGTFLLRFSESSK
Molecular formula
C₁₄₆H₂₃₈N₄₀O₄₂.C₂HF₃O₂
Physical appearance
Lyophilized solid
Supplied with
N/A
Is this a salt?
Yes
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
H₂O
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.