IGF-BP2, human recombinant

Catalog number
7165-50
Name
IGF-BP2, human recombinant
Size
50 μg
Price
965.00 EUR
Supplier

Details

Synonyms
IBP-2
Alternates names
IBP-2
Taglines
Inhibits IGF-II action in human breast and ovarian carcinoma cells
Biomolecule/Target
IGF-BP2
NCBI Gene ID #.
3485
NCBI Gene Symbol
IGFBP2
Gene Source
Human
Accession #
P18065
Recombinant
Yes
Source
(BTI-Tn-5B1-4) Hi-5 Insect cells
Purity
N/A
Endotoxin Level
<0.1 ng/μg of protein (
Activity (Specifications/test method)
Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Biological activity
Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Results
N/A
Molecular Weight
31.5 kDa
Storage Temp.
-20°C
Shipping
Gel Pack
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized powder
Physical form description
Sterile filtered through a 0.2 micron filter. Lyophilized from 1 x PBS, pH 7.2.
Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Additional source
Recombinants or rec. proteins
Group
recombinants