Calpain Inhibitor II, ALLM for cell activation

Catalog number
1835-5
Name
Calpain Inhibitor II, ALLM for cell activation
Size
5 mg
Price
159.00 EUR
Supplier

Details

Description
A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
Peptide sequence
N-Acetyl-Leu-Leu-Methional
CAS number
136632-32-1
Molecular weight
401.57
Category
Biochemicals
Other name
Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional
Molecular formula
C₁₉H₃₅N₃O₄S
Physical appearance
White powder
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO (25 mg/ml) or EtOH (25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from moisture and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.