USP14 Inhibitor, IU1 for cell activation

Catalog number
1845-5
Name
USP14 Inhibitor, IU1 for cell activation
Size
5 mg
Price
137.00 EUR
Supplier

Details

Description
A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM.
Peptide sequence
N/A
CAS number
314245-33-5
Molecular weight
300.37
Category
Biochemicals
Other name
1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone
Molecular formula
C₁₈H₂₁FN₂O
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.