NSC 146109 hydrochloride for cell activation

Catalog number
1907-5
Name
NSC 146109 hydrochloride for cell activation
Size
5 mg
Price
191.00 EUR
Supplier

Details

Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
Peptide sequence
N/A
CAS number
59474-01-0
Molecular weight
316.85
Category
Biochemicals
Other name
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
Molecular formula
C₁₇H₁₆N₂S.HCl
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (100 mM) or EtOH (10 mM)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.