BI-D1870 for cell activation

Catalog number
1924-5
Name
BI-D1870 for cell activation
Size
5 mg
Price
371.00 EUR
Supplier

Details

Description
Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC₅₀'s at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.
Peptide sequence
N/A
CAS number
501437-28-1
Molecular weight
391.42
Category
Biochemicals
Other name
2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Molecular formula
C₁₉H₂₃F₂N₅O₂
Physical appearance
Pale orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (>25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.