SU 11274 for cell activation

Catalog number
1938-5
Name
SU 11274 for cell activation
Size
5 mg
Price
208.00 EUR
Supplier

Details

Description
A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC₅₀ values: Met = 0.02 μM, Flk = 1.3 μM, EGFR =>100 μM, PDGFßR =>20 μM, Tie2 =>100 μM, c-src =>10 μM, cdk2 =>10 μM, and FGFR-1 = 9.7 μM). Inhibition of the Met kinase activity by SU11274 leads to time- and dose-dependent reduced cell growth and induced G1 cell cycle arrest and apoptosis.
Peptide sequence
N/A
CAS number
658084-23-2
Molecular weight
568.09
Category
Biochemicals
Other name
3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
Molecular formula
C₂₈H₃₀ClN₅O₄S
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 10 mg/ml on warming)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.