SANT-1 for cell activation

Catalog number
1978-1
Name
SANT-1 for cell activation
Size
1 mg
Price
126.00 EUR
Supplier

Details

Description
Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
Peptide sequence
N/A
CAS number
304909-07-7
Molecular weight
373.49
Category
Biochemicals
Other name
N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine
Molecular formula
C₂₃H₂₇N₅
Physical appearance
Pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~50 mM) or EtOH (~25 mM)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
60 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.