Syk Inhibitor for cell activation

Catalog number
1983-1
Name
Syk Inhibitor for cell activation
Size
1 mg
Price
126.00 EUR
Supplier

Details

Description
Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM).
Peptide sequence
N/A
CAS number
622387-85-3
Molecular weight
353.39
Category
Biochemicals
Other name
Spleen Tyrosine Kinase Inhibitor
Molecular formula
C₁₈H₁₅N₃O₃S
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC (sum of two isomers)
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
60 months
Storage instructions
Protect from light and mositure
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.